Breakthrough in Virology

Look here for the latest groundbreaking findings in virology research:

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.

Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F, Nguyen HN, Itkin M, Hanna C, Shinn P, Allen C, Michael SG, Simeonov A, Huang W, Christian KM, Goate A, Brennand KJ, Huang R, Xia M, Ming GL, Zheng W, Song H, Tang H.

Nat Med. 2016 Aug 29. doi: 10.1038/nm.4184

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection.

Barrows NJ, Campos RK, Powell ST, Prasanth KR, Schott-Lerner G, Soto-Acosta R, Galarza-Muñoz G, McGrath EL, Urrabaz-Garza R, Gao J, Wu P, Menon R, Saade G, Fernandez-Salas I, Rossi SL, Vasilakis N, Routh A, Bradrick SS, Garcia-Blanco MA.

Cell Host Microbe. 2016 Aug 10;20(2):259-70. doi: 10.1016/j.chom.2016.07.004. Epub 2016 Jul 28.

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses.

Zhang R, Miner JJ, Gorman MJ, Rausch K, Ramage H, White JP, Zuiani A, Zhang P, Fernandez E, Zhang Q, Dowd KA, Pierson TC, Cherry S, Diamond MS.

Nature. 2016 Jul 7;535(7610):164-8.

Zika Virus Associated with Microcephaly.

Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, Kolenc M, Resman Rus K, Vesnaver Vipotnik T, Fabjan Vodušek V, Vizjak A, Pižem J, Petrovec M, Avšič Županc T.

N Engl J Med. 2016 Feb 10. [Epub ahead of print]

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.

Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, Haworth KG, Decker JM, Alpert MD, Bailey CC, Neale ES, Fellinger CH, Joshi VR, Fuchs SP, Martinez-Navio JM, Quinlan BD, Yao AY, Mouquet H, Gorman J, Zhang B, Poignard P, Nussenzweig MC, Burton DR, Kwong PD9, Piatak M, Lifson JD, Gao G, Desrosiers RC, Evans DT, Hahn BH, Ploss A, Cannon PM, Seaman MS, Farzan M.

Nature. 2015 Feb 18. doi:10.1038/nature14264.

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

Warren TK, Wells J, Panchal RG, Stuthman KS, Garza NL, Van Tongeren SA, Dong L, Retterer CJ, Eaton BP, Pegoraro G, Honnold S, Bantia S, Kotian P, Chen X, Taubenheim BR, Welch LS, Minning DM, Babu YS, Sheridan WP, Bavari S.

Nature. 2014 Apr 17. doi: 10.1038/nature13027.

Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.

Akey DL, Brown WC, Dutta S, Konwerski J, Jose J, Jurkiw TJ, DelProposto J, Ogata CM, Skiniotis G, Kuhn RJ, Smith JL.

Science. 2014 Feb 21;343(6173):881-5. doi: 10.1126/science.1247749.

Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.

Tan Q, Zhu Y, Li J, Chen Z, Han GW, Kufareva I, Li T, Ma L, Fenalti G, Li J, Zhang W, Xie X, Yang H, Jiang H, Cherezov V, Liu H, Stevens RC, Zhao Q, Wu B.

Science. 2013 Sep 20;341(6152):1387-90. doi: 10.1126/science.1241475.

Press release from the Scripps research institute.

Immune clearance of highly pathogenic SIV infection.

Hansen SG, Jr MP, Ventura AB, Hughes CM, Gilbride RM, Ford JC, Oswald K, Shoemaker R, Li Y, Lewis MS, Gilliam AN, Xu G, Whizin N, Burwitz BJ, Planer SL, Turner JM, Legasse AW, Axthelm MK, Nelson JA, Früh K, Sacha JB, Estes JD, Keele BF, Edlefsen PT, Lifson JD, Picker LJ.

Nature. 2013 Sep 11. doi: 10.1038/nature12519.

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.

Goujon C, Moncorgé O, Bauby H, Doyle T, Ward CC, Schaller T, Hué S, Barclay WS, Schulz R, Malim MH.

Nature. 2013 Sep 18. doi: 10.1038/nature12542.

MX2 is an interferon-induced inhibitor of HIV-1 infection.

Kane M, Yadav SS, Bitzegeio J, Kutluay SB, Zang T, Wilson SJ, Schoggins JW, Rice CM, Yamashita M, Hatziioannou T, Bieniasz PD.

Nature. 2013 Oct 24. doi: 10.1038/nature12653.

The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection.

Liu Z, Pan Q, Ding S, Qian J, Xu F, Zhou J, Cen S, Guo F, Liang C.

Cell Host Microbe. 2013 Oct 16. doi: 10.1016/j.chom.2013.08.015.

Referred to by Otto Haller: Dynamins Are Forever: MxB Inhibits HIV-1

Cell Host Microbe. 2013 Oct 16. doi: 10.1016/j.chom.2013.10.002.