PhD in Retrovirology
We are looking for a talented and highly motivated PhD student to join the research group “Retrovirus Transmission” of Dr. Xaver Sewald at the Max von Pettenkofer-Institute, Department of Virology at the LMU Munich. The position is initially funded for 36 months by the DFG (TV-L E13, 65%) and is available from May 2018.
The project focuses on the mechanism of retrovirus cell-to-cell transmission. Cell contactdependent pathways of retrovirus spread will be studied using the murine leukemia virus as a model system (Sewald et al., Nature Communications 3:1320 (2012); Sewald et al., Science 350:563 (2015)). Using visual approaches we seek to understand how retroviruses exploit cellcell interactions for transmission and infection. This will be studied in a primary leukocyte system in vitro using advanced live cell fluorescence imaging. Single cell assays will help to dissect the mechanism of retrovirus cell-to-cell transmission. In addition, state-of-the-art intravital imaging will reveal retrovirus spread in a mouse model under physiological conditions in vivo.
Applicants should be strongly committed to basic science with great interest in infectious diseases and the ability to conduct independent research. Because of the experimental design, experience with imaging techniques (live cell imaging and/or multi-photon intravital microscopy), single cell approaches or animal models would be an asset, but is not mandatory. The PhD position requires a master´s degree/diploma in life sciences or related disciplines.
This is a great opportunity to work on an exciting research topic in a stimulating research environment. If you would like to join, please send your application (letter of motivation, CV with publication list, certificates and 2 reference contacts) by e-mail to (pdf files only):
Dr. Xaver Sewald
Max von Pettenkofer-Institut, Virologie
Tel.: +49 (0)89 – 2180 78136
The Division for Molecular Virology of Human Infectious Diseases at the University Hospital Tübingen, Germany (Prof. Dr. Michael Schindler), invites candidates to apply for a vacancy with the following project:
Postdoc/PhD Student in Molecular Virology
‐ to study intracellular trafficking and release of hepatitis c virus.
‐ to functionally characterize and optimize a novel pan‐flavivirus inhibitor.
We have open positions in both projects for PhD students or a Postdoc which are initially funded for 36 months by the DFG and the BW Stiftung.
The project aiming to delineate intracellular transport and release of HCV involves advanced super‐resolution live cell fluorescence imaging in our BSL‐3 facility. Therefore, experience with live cell imaging and the according data handling would be an asset. Furthermore, we have set up novel techniques to identify and characterize viral protein interactions.
Advantageous, but not mandatory, is a background in:
- HCV virological assays
- live cell imaging
- basic molecular biology techniques (PCR, cloning)
The work on our novel pan‐flavivirus inhibitor is an interdisciplinary project embedded at the border between molecular virology and structural biology/pharmaceutical chemistry. We aim to optimize our primary hit by rationale‐based SAR involving structural characterization, in silico modelling and resistance screening. Advantageous is a background in:
- HCV virological assays
- Structural biology
- basic molecular biology techniques (PCR, cloning)
This is an opportunity to work together with a vibrant team in a productive and stimulating environment and to perform research on an exciting and highly relevant topic. We seek highly motivated candidates with a strong dedication to science. If you would like to join us in combating viral human diseases, please send your application as one PDF file (Letter of motivation, CV, degrees and certificates, reference letters) preferentially by E‐mail. We offer remuneration in accordance with TV‐L (collective wage agreement for the Public Service of the German Federal States) in addition to all the customary benefits granted to employees working in Public Services. Severely handicapped persons with equal qualifications are given preferential consideration. The University of Tübingen is anxious to increase its quota of female scientific staff, and therefore emphatically requests women to apply for this position. The Administration of the University Hospital is responsible for all employment matters. Personnel appointments will be made pursuant to the fundamental stipulations of the legal statutes for universities in Germany. Interview expenses are not covered.
Send your application preferentially by Email as one PDF file (reference # 8710) to:
Prof. Dr. Michael Schindler, Tel.: +49‐(0)7071‐29‐87459
University Hospital Tübingen
Institut for Medical Virology and Epidemiology
72076 Tübingen, Germany
Closing date: 31.05.2018.
Open Positions for Postdoctoral Fellows
in Molecular Immunology and Infection Biology
Short Summary: The Bergthaler laboratory at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna, Austria is looking for Postdoctoral Fellows who strive to study fundamental molecular questions in the areas of viral infections, inflammation and immunity. Hypothesis- and data-driven approaches are integrated to address pertinent pathophysiological questions on the organ/organism level (Ref: e.g. Schliehe C et al. Nature Immunology 2015 (PMID: 25419628), Bhattacharya A et al. Immunity 2015 (PMID: 26588782), Khamina K et al. PLoS Pathogens 2017 (PMID: 292618079)).
Project 1: Metabolite-driven inflammation in viral hepatitis.
How do metabolic-inflammatory hubs modulate antiviral T cells and liver pathology? By using in vivo infection models and latest technologies (CRISPR screens, single cell sequencing, metabolomics, flux measurements) we aim to unravel critical processes between metabolism and inflammation in tissue. This may open avenues to tailor local and systemic immunological responses and ameliorate tissue pathology.
Project 2: Impact of chromatin-associated proteins in inflammation.
This project will focus on the yet unexplored role of specific chromatin-associated proteins during infections and sterile inflammatory diseases. Newly generated gene-targeted mouse models and immunological and virological assays will be coupled to systems-level approaches (ChIP-seq, RNA-seq) to identify novel mechanisms of immunoregulation that are relevant to inflammation during infections and autoimmunity.
Both projects will benefit from established in vivo disease models, unpublished data, strong bioinformatics support, access to world class core facilities (next-generation sequencing, metabolomics, proteomics, drug screens), a highly international environment and a vibrant collaborative network with leading scientists.
- PhD in a relevant field (e.g. Molecular Biology, Immunology, Virology, Genomics, Epigenetics, Tissue Biology, Computational Biology, Technology Development).
- Alternatively, you have a MD/DVM degree and strong interests in mechanistic molecular research.
- Strong publication track record with at least one first-author paper in a reputated peer-reviewed journal.
- Expertise in molecular biology, immunology and animal models.
- Additional skillsets (e.g. histology, screening assays, data analysis, modeling) are welcomed assets.
- Critical, creative and proactive mindset.
- Teamplayer with strong interdisciplinary communication skills.
The PI: Dr. Bergthaler received training in premier laboratories at the University/ETH Zurich, University of Tokyo and at the Institute for Systems Biology in Seattle. His team currently consists of 10 members representing 6 nationalities, who closely collaborate across projects. The lab is funded by intramural funds from the Austrian Academy of Sciences and competitive grants (European Research Council (ERC), Austrian Science Fund (FWF)). More information about the PI and the lab: http://www.bergthaler1.at
The Institute: CeMM is an international research institute of the Austrian Academy of Sciences and founding member of EU-LIFE (http://eu-life.eu). CeMM is a leading biomedical research institute in Europe and provides a collaborative, dynamic and personal environment. The official language at CeMM is English with more than 40 nationalities present at the institute. CeMM aims to promote equality of opportunity for all with the right mix of talent, competences, and potential and thus we welcome applications from candidates with diverse backgrounds. More information about CeMM: http://cemm.at/
Please submit your application at https://cemm.jobbase.io/job/f6rex65c and include a cover letter, CV, academic transcripts, and contact details of three referees.
Applications will be reviewed on a rolling basis. Starting dates are flexible. The annual salary of approximately 50,000 EUR (gross) is paid according to the FWF salary scheme.
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