Job market

PhD Student (d,f,m)

Host range determinants of arbovirus infections

The Heinrich Pette Institute – Leibniz Institute for Experimental Virology (HPI), is committed to research on the biology of different human viruses as well as the pathogenesis of viral diseases (http://www.hpi-hamburg.de). The HPI offers the opportunity to perform cutting-edge research in a world-class research environment with excellent technical facilities. In recent years, concomitant with the broader distribution of the Aedes and Culex mosquito vectors, the number of insect-borne virus infections has increased dramatically. However, our understanding of the interaction between arboviruses and their mosquito vector remains rudimentary.
We are looking for a highly motivated PhD student with eagerness to learn, work in a team and make fundamental discoveries. Applicants should hold a MSc degree (or equivalent) with focus on cell biology, virology or related disciplines. Ability to plan experiments, develop methods and carry out analyses is a requirement. Prior experience in virology, mass- spectrometry or fluorescence microscopy would be a plus.
The project aims at identifying new mosquito host factors supporting or restricting arbovirus infections and unraveling their function. In addition to traditional virology and molecular/cellular biology methods, the candidate will employ state-of-the-art bottom-up mass-spectrometry and quantitative imaging to identify and characterize new critical host-pathogen interaction in insect cells. The project will be carried in the junior research groups “Systems Arbovirology” of Pietro Scaturro and “Cell biology of RNA viruses” of Gabrielle Vieyres as a joint project, to characterize host-dependency and restriction factors in the mosquito host.
We offer a PhD position, starting as early as possible, with an initial 3-year contract and possibility for extension. Payment and social benefits are in accordance with regulations of the German TV-AVH (salary agreement public service employees).
Applications should include a CV, a cover letter highlighting the specific qualifications and indicating the earliest starting date, copies of transcripts and up to three references, in a single PDF. Please submit your application by January 15th, 2020. Late applications may be considered until the position is filled. For questions, please do not hesitate to contact Dr. Pietro Scaturro (Email: pietro.scaturro@leibniz-hpi.de) or Dr. Gabrielle Vieyres directly (Email: gabrielle.vieyres@leibniz-hpi.de).
The Heinrich-Pette-Institute promotes the professional equality between women and men. Handicapped applicants with equal qualifications will be given preferential treatment.

Heinrich Pette Institute – Leibniz Institute for Experimental Virology
Personnel Department
Martinistraße 52, 20251 Hamburg
personnel@leibniz-hpi.de


November 23rd 2020
Postdoc/PhD-student positions available:

Development of broadly acting antivirals targeting conserved host cell mechanisms and viral structures.

PI: Prof. Michael Schindler, Institute for Medical Virology, Tübingen, Germany

Synopsis: The SARS-CoV-2 pandemic and its devastating impact on mankind, considering not only the viral death toll but also the socioeconomic consequences of the pandemic, emphasizes the importance of conducting research in antiviral therapy. There is a constant threat of emerging and re-emerging viral pathogens that ultimately might have the potential to cause pandemics in a manner comparable to SARS-CoV-2. Hence, even though there is hope for an effective vaccine against SARS-CoV-2, the development of broadly acting antivirals is a top priority to be prepared for potential novel viral pathogens. The Research Section Molecular Virology at the University Hospital Tübingen has several developmental projects aiming to establish novel broadly acting antivirals. Our purpose is to identify and target either conserved viral structural elements or host cell pathways that are exploited by viruses for replication.
Objectives: In previous work, we have identified several promising hit candidates that show broad antiviral activity against a range of different viruses within virus families or even across them. The goal of the research project is, in a highly collaborative effort, to determine the exact IC50s of the compounds to act on various human pathogenic viruses including DENV, HIV-1, SARS-CoV-2, and HCMV in relevant cell culture models. Your task will be to identify and validate target structures, investigate the compound mode of action, perform SAR-optimization, and carry out resistance as well as toxicity screenings.
Study organization: You will be embedded in a highly motivated team of Postdocs and PhDstudents working in the field of antiviral research. We have on-site collaborations with
pharmaceutical chemists, bioinformaticians for in silico modeling and systems biology, structural biologists, and clinicians. Furthermore, we collaborate with several industrial partners with the ultimate goal to advance compounds into a clinical development stage.
Your profile: You are a highly-motivated PhD-student/postdoctoral scientist thrilled to pursue a career in academia. You have a collaborative vision of science; you are communicative, selforganized, and reliable. You have a strong interest or scientific background in virology, structural biology, or related fields. Ideally, you have worked with BSL3 pathogens (for instance flaviviruses, coronaviruses, influenza, retroviruses) and you have experience in protein production, purification, and advanced biochemistry necessary for structural analyses. We consider these technical skills an asset, but not absolutely required.
Contact for inquiries and to send your application documents:
Prof. Dr. Michael Schindler, University Hospital Tübingen, Institute for Medical Virology,
Research Section Molecular Virology, Germany; michael.schindler@med.uni-tuebingen.de
The positions are available immediately (from December 2020 on). Applications will be screened on a rolling basis until the positions are filled.
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